Institute for Molecular Medicine Finland (FIMM)

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  1. 2010
  2. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

    Saxena, R., Hivert, M-F., Langenberg, C., Tanaka, T., Pankow, J. S., Vollenweider, P., Lyssenko, V., Bouatia-Naji, N., Dupuis, J., Jackson, A. U., Kao, W. H. L., Li, M., Glazer, N. L., Manning, A. K., Luan, J., Stringham, H. M., Prokopenko, I., Johnson, T., Grarup, N., Boesgaard, T. W., Lecoeur, C., Shrader, P., O'Connell, J., Ingelsson, E., Couper, D. J., Rice, K., Song, K., Andreasen, C. H., Dina, C., Koettgen, A., Le Bacquer, O., Pattou, F., Taneera, J., Steinthorsdottir, V., Rybin, D., Ardlie, K., Sampson, M., Qi, L., van Hoek, M., Weedon, M. N., Aulchenko, Y. S., Voight, B. F., Grallert, H., Balkau, B., Bergman, R. N., Bielinski, S. J., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Boettcher, Y., Brunner, E., Buchanan, T. A., Bumpstead, S. J., Cavalcanti-Proenca, C., Charpentier, G., Chen, Y-D. I., Chines, P. S., Collins, F. S., Cornelis, M., Crawford, G. J., Delplanque, J., Doney, A., Egan, J. M., Erdos, M. R., Firmann, M., Forouhi, N. G., Fox, C. S., Goodarzi, M. O., Graessler, J., Hingorani, A., Isomaa, B., Jorgensen, T., Kivimäki, M., Kovacs, P., Krohn, K., Kumari, M., Lauritzen, T., Levy-Marchal, C., Mayor, V., McAteer, J. B., Meyre, D., Mitchell, B. D., Mohlke, K. L., Morken, M. A., Narisu, N., Palmer, C. N. A., Pakyz, R., Pascoe, L., Payne, F., Pearson, D., Rathmann, W., Sandbaek, A., Sayer, A. A., Scott, L. J., Sharp, S. J., Sijbrands, E., Singleton, A., Siscovick, D. S., Smith, N. L., Sparso, T., Swift, A. J., Syddall, H., Thorleifsson, G., Toenjes, A., Tuomi, T., Tuomilehto, J., Valle, T. T., Waeber, G., Walley, A., Waterworth, D. M., Zeggini, E., Zhao, J. H., Illig, T., Wichmann, H. E., Wilson, J. F., van Duijn, C., Hu, F. B., Morris, A. D., Frayling, T. M., Hattersley, A. T., Thorsteinsdottir, U., Stefansson, K., Nilsson, P., Syvanen, A-C., Shuldiner, A. R., Walker, M., Bornstein, S. R., Schwarz, P., Williams, G. H., Nathan, D. M., Kuusisto, J., Laakso, M., Cooper, C., Marmot, M., Ferrucci, L., Mooser, V., Stumvoll, M., Loos, R. J. F., Altshuler, D., Psaty, B. M., Rotter, J. I., Boerwinkle, E., Hansen, T., Pedersen, O., Florez, J. C., McCarthy, M. I., Boehnke, M., Barroso, I., Sladek, R., Froguel, P., Meigs, J. B., Groop, L., Wareham, N. J., Watanabe, R. M. & GIANT Consortium, MAGIC Investigators 2010 In : Nature Genetics. 42, 2, p. 142-148 7 p.

    Publication: Contribution to journalA1 Refereed journal article

  3. Genetic variation of the interleukin-1 family and nongenetic factors determining the interleukin-1 receptor antagonist phenotypes

    Luotola, K., Pietilä, A., Kinnunen, M., Lanki, T., Loo, B-M., Jula, A., Perola, M., Peters, A., Zeller, T., Blankenberg, S. & Salomaa, V. 2010 In : Metabolism, clinical and experimental. 59, 10, p. 1520-1527 8 p.

    Publication: Contribution to journalA1 Refereed journal article

  4. Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

    Pillas, D., Hoggart, C. J., Evans, D. M., O'Reilly, P. F., Sipila, K., Lahdesmaki, R., Millwood, I. Y., Kaakinen, M., Netuveli, G., Blane, D., Charoen, P., Sovio, U., Pouta, A., Freimer, N., Hartikainen, A-L., Laitinen, J., Vaara, S., Glaser, B., Crawford, P., Timpson, N. J., Ring, S. M., Deng, G., Zhang, W., McCarthy, M. I., Deloukas, P., Peltonen, L., Elliott, P., Coin, L. J. M., Smith, G. D. & Jarvelin, M-R. 2010 In : PLoS Genetics. 6, 7 p.

    Publication: Contribution to journalA1 Refereed journal article

  5. Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF-kappa B Signaling

    Valanne, S., Myllymäki, H., Kallio, J., Schmid, M. R., Kleino, A., Murumägi, A., Airaksinen, L., Kotipelto, T., Kaustio, M., Ulvila, J., Esfahani, S. S., Engström, Y., Silvennoinen, O., Hultmark, D., Parikka, M. & Rämet, M. 2010 In : Journal of Immunology. 184, 11, p. 6188-6198 11 p.

    Publication: Contribution to journalA1 Refereed journal article

  6. Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

    Jakkula, E., Leppa, V., Sulonen, A-M. K., Varilo, T., Kallio, S., Kemppinen, A., Purcell, S., Koivisto, K., Tienari, P., Sumelahti, M-L., Elovaara, I., Pirttila, T., Reunanen, M., Aromaa, A., Oturai, A. B., Sondergaard, H. B., Harbo, H. F., Mero, I-L., Gabriel, S. B., Mirel, D. B., Hauser, S. L., Kappos, L., Polman, C., De Jager, P. L., Hafler, D. A., Daly, M. J., Palotie, A., Saarela, J. & Peltonen, L. 2010 In : American Journal of Human Genetics. 86, 2, p. 285-291 7 p.

    Publication: Contribution to journalA1 Refereed journal article

  7. Genome-wide association study identifies five loci associated with lung function

    Repapi, E., Sayers, I., Wain, L. V., Burton, P. R., Johnson, T., Obeidat, M., Zhao, J. H., Ramasamy, A., Zhai, G., Vitart, V., Huffman, J. E., Igl, W., Albrecht, E., Deloukas, P., Henderson, J., Granell, R., McArdle, W. L., Rudnicka, A. R., Barroso, I., Loos, R. J. F., Wareham, N. J., Mustelin, L., Rantanen, T., Surakka, I. L., Imboden, M., Wichmann, H. E., Grkovic, I., Jankovic, S., Zgaga, L., Hartikainen, A-L., Peltonen, L., Gyllensten, U., Johansson, A., Zaboli, G., Campbell, H., Wild, S. H., Wilson, J. F., Glaeser, S., Homuth, G., Voelzke, H., Mangino, M., Soranzo, N., Spector, T. D., Polasek, O., Rudan, I., Wright, A. F., Heliovaara, M., Ripatti, S. O., Pouta, A., Naluai, A. T., Olin, A-C., Toren, K., Cooper, M. N., James, A. L., Palmer, L. J., Hingorani, A. D., Wannamethee, S. G., Whincup, P. H., Smith, G. D., Ebrahim, S., McKeever, T. M., Pavord, I. D., MacLeod, A. K., Morris, A. D., Porteous, D. J., Cooper, C., Dennison, E., Shaheen, S., Karrasch, S., Schnabel, E., Schulz, H., Grallert, H., Bouatia-Naji, N., Delplanque, J., Froguel, P., Blakey, J. D., Britton, J. R., Morris, R. W., Holloway, J. W., Lawlor, D. A., Hui, J., Nyberg, F., Jarvelin, M-R., Jackson, C., Kahonen, M., Kaprio, J., Probst-Hensch, N. M., Koch, B., Hayward, C., Evans, D. M., Elliott, P., Strachan, D. P., Hall, I. P., Tobin, M. D. & Wellcome Trust Case Control Consor, NSHD Resp Study Team 2010 In : Nature Genetics. 42, p. 36-44 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  8. Genome-wide association study of intracranial aneurysm identifies three new risk loci

    Yasuno, K., Bilguvar, K., Bijlenga, P., Low, S-K., Krischek, B., Auburger, G., Simon, M., Krex, D., Arlier, Z., Nayak, N., Ruigrok, Y. M., Niemela, M., Tajima, A., Fraunberg, M. V. U. Z., Doczi, T., Wirjatijasa, F., Hata, A., Blasco, J., Oszvald, A., Kasuya, H., Zilani, G., Schoch, B., Singh, P., Stueer, C., Risselada, R., Beck, J., Sola, T., Ricciardi, F., Aromaa, A., Illig, T., Schreiber, S., van Duijn, C. M., van den Berg, L. H., Perret, C., Proust, C., Roder, C., Ozturk, A. K., Gaal, E., Berg, D., Geisen, C., Friedrich, C. M., Summers, P., Frangi, A. F., State, M. W., Wichmann, H. E., Breteler, M. M. B., Wijmenga, C., Mane, S., Peltonen, L., Elio, V., Sturkenboom, M. C. J. M., Lawford, P., Byrne, J., Macho, J., Sandalcioglu, E. I., Meyer, B., Raabe, A., Steinmetz, H., Ruefenacht, D., Jaaskelainen, J. E., Hernesniemi, J., Rinkel, G. J. E., Zembutsu, H., Inoue, I., Palotie, A., Cambien, F., Nakamura, Y., Lifton, R. P. & Guenel, M. 2010 In : Nature Genetics. 42, p. 420-69 8 p.

    Publication: Contribution to journalA1 Refereed journal article

  9. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1

    Anttila, V., Stefansson, H., Kallela, M., Todt, U., Terwindt, G. M., Calafato, M. S., Nyholt, D. R., Dimas, A. S., Freilinger, T., Mueller-Myhsok, B., Artto, V., Inouye, M., Alakurtti, K., Kaunisto, M. A., Hämäläinen, E., de Vries, B., Stam, A. H., Weller, C. M., Heinze, A., Heinze-Kuhn, K., Goebel, I., Borck, G., Goebel, H., Steinberg, S., Wolf, C., Bjoernsson, A., Gudmundsson, G., Kirchmann, M., Hauge, A., Werge, T., Schoenen, J., Eriksson, J. G., Hagen, K., Stovner, L., Wichmann, E., Meitinger, T., Alexander, M., Moebus, S., Schreiber, S., Aulchenko, Y. S., Breteler, M. M. B., Uitterlinden, A. G., Hofman, A., van Duijn, C. M., Tikka-Kleemola, P., Vepsäläinen, S., Lucae, S., Tozzi, F., Muglia, P., Barrett, J., Kaprio, J., Färkkilä, M., Palotie, L., Stefansson, K., Zwart, J-A., Ferrari, M. D., Olesen, J., Daly, M., Wessman, M., van den Maagdenberg, A. M. J. M., Dichgans, M., Kubisch, C., Dermitzakis, E. T., Frants, R. R., Palotie, A. & Int Headache Genetics Consortium 2010 In : Nature Genetics. 42, 10, p. 869-873 5 p.

    Publication: Contribution to journalA1 Refereed journal article

  10. Genome-wide meta-analyses identify multiple loci associated with smoking behavior

    Furberg, H., Kim, Y., Dackor, J., Boerwinkle, E., Franceschini, N., Ardissino, D., Bernardinelli, L., Mannucci, P. M., Mauri, F., Merlini, P. A., Absher, D., Assimes, T. L., Fortmann, S. P., Iribarren, C., Knowles, J. W., Quertermous, T., Ferrucci, L., Tanaka, T., Bis, J. C., Furberg, C. D., Haritunians, T., McKnight, B., Psaty, B. M., Taylor, K. D., Thacker, E. L., Almgren, P., Groop, L., Ladenvall, C., Boehnke, M., Jackson, A. U., Mohlke, K. L., Stringham, H. M., Tuomilehto, J., Benjamin, E. J., Hwang, S-J., Levy, D., Preis, S. R., Vasan, R. S., Duan, J., Gejman, P. V., Levinson, D. F., Sanders, A. R., Shi, J., Lips, E. H., Mckay, J. D., Agudo, A., Barzan, L., Bencko, V., Benhamou, S., Castellsague, X., Canova, C., Conway, D. I., Fabianova, E., Foretova, L., Janout, V., Healy, C. M., Holcatova, I., Kjaerheim, K., Lagiou, P., Lissowska, J., Lowry, R., Macfarlane, T. V., Mates, D., Richiardi, L., Rudnai, P., Szeszenia-Dabrowska, N., Zaridze, D., Znaor, A., Lathrop, M., Brennan, P., Bandinelli, S., Frayling, T. M., Guralnik, J. M., Milaneschi, Y., Perry, J. R. B., Altshuler, D., Elosua, R., Kathiresan, S., Lucas, G., Melander, O., O'Donnell, C. J., Salomaa, V., Schwartz, S. M., Voight, B. F., Penninx, B. W., Smit, J. H., Vogelzangs, N., Boomsma, D. I., de Geus, E. J. C., Vink, J. M., Willemsen, G., Chanock, S. J., Gu, F., Hankinson, S. E., Hunter, D. J., Hofman, A., Tiemeier, H., Uitterlinden, A. G., van Duijn, C. M., Walter, S., Chasman, D. I., Everett, B. M., Pare, G., Ridker, P. M., Li, M. D., Maes, H. H., Audrain-McGovern, J., Posthuma, D., Thornton, L. M., Lerman, C., Kaprio, J., Rose, J. E., Ioannidis, J. P. A., Kraft, P., Lin, D-Y. & Sullivan, P. F. 2010 In : Nature Genetics. 42, p. 441-447 8 p.

    Publication: Contribution to journalA1 Refereed journal article

  11. Genomic landscape of positive natural selection in Northern European populations

    Lappalainen, T., Salmela, E., Andersen, P. M., Dahlman-Wright, K., Sistonen, P., Savontaus, M-L., Schreiber, S., Lahermo, P. & Kere, J. 2010 In : European Journal of Human Genetics. 2010, 18, p. 471-478 8 p.

    Publication: Contribution to journalA1 Refereed journal article