Institute for Molecular Medicine Finland (FIMM)

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  1. 2016
  2. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

    van Leeuwen, E. M., Sabo, A., Bis, J. C., Huffman, J. E., Manichaikul, A., Smith, A. V., Feitosa, M. F., Demissie, S., Joshi, P. K., Duan, Q., Marten, J., van Klinken, J. B., Surakka, I., Nolte, I. M., Zhang, W., Mbarek, H., Li-Gao, R., Trompet, S., Verweij, N., Evangelou, E., Lyytikainen, L-P., Tayo, B. O., Deelen, J., van der Most, P. J., van der Laan, S. W., Arking, D. E., Morrison, A., Dehghan, A., Franco, O. H., Hofman, A., Rivadeneira, F., Sijbrands, E. J., Uitterlinden, A. G., Mychaleckyj, J. C., Campbell, A., Hocking, L. J., Padmanabhan, S., Brody, J. A., Rice, K. M., White, C. C., Harris, T., Isaacs, A., Campbell, H., Lange, L. A., Rudan, I., Kolcic, I., Navarro, P., Zemunik, T., Salomaa, V., Kooner, A. S., Kooner, J. S., Lehne, B., Scott, W. R., Tan, S-T., de Geus, E. J., Milaneschi, Y., Penninx, B. W. J. H., Willemsen, G., de Mutsert, R., Ford, I., Gansevoort, R. T., Segura-Lepe, M. P., Raitakari, O. T., Viikari, J. S., Nikus, K., Forrester, T., McKenzie, C. A., de Craen, A. J. M., de Ruijter, H. M., Pasterkamp, G., Snieder, H., Oldehinkel, A. J., Slagboom, P. E., Cooper, R. S., Kahonen, M., Lehtimaki, T., Elliott, P., van der Harst, P., Jukema, J. W., Mook-Kanamori, D. O., Boomsma, D. I., Chambers, J. C., Swertz, M., Ripatti, S., van Dijk, K. W., Vitart, V., Polasek, O., Hayward, C., Wilson, J. G., Wilson, J. F., Gudnason, V., Rich, S. S., Psaty, B. M., Borecki, I. B., Boerwinkle, E., Rotter, J. I., Cupples, L. A., van Duijn, C. M. & CHARGE Lipids Working Grp Jul 2016 In : Journal of Medical Genetics. 53, 7, p. 441-449 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  3. Transcriptional response networks for elucidating mechanisms of action of multitargeted agents

    Kibble, M., Khan, S. A., Saarinen, N., Iorio, F., Saez-Rodriguez, J., Makela, S. & Aittokallio, T. Jul 2016 In : Drug Discovery Today. 21, 7, p. 1063-1075 13 p.

    Publication: Contribution to journalA2 Review in scientific journal

  4. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

    Jelenkovic, A., Sund, R., Hur, Y-M., Yokoyama, Y., Hjelmborg, J. V. B., Moller, S., Honda, C., Magnusson, P. K. E., Pedersen, N. L., Ooki, S., Aaltonen, S., Stazi, M. A., Fagnani, C., D'Ippolito, C., Freitas, D. L., Maia, J. A., Ji, F., Ning, F., Pang, Z., Rebato, E., Busjahn, A., Kandler, C., Saudino, K. J., Jang, K. L., Cozen, W., Hwang, A. E., Mack, T. M., Gao, W., Yu, C., Li, L., Corley, R. P., Huibregtse, B. M., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Heikkila, K., Wardle, J., Llewellyn, C. H., Fisher, A., McAdams, T. A., Eley, T. C., Gregory, A. M., He, M., Ding, X., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A. D., Tarnoki, D. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Burt, S. A., Klump, K. L., Silberg, J. L., Eaves, L. J., Maes, H. H., Krueger, R. F., McGue, M., Pahlen, S., Gatz, M., Butler, D. A., Bartels, M., van Beijsterveldt, T. C. E. M., Craig, J. M., Saffery, R., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Martin, N. G., Medland, S. E., Montgomery, G. W., Swan, G. E., Krasnow, R., Tynelius, P., Lichtenstein, P., Haworth, C. M. A., Plomin, R., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Spector, T., Mangino, M., Lachance, G., Baker, L. A., Tuvblad, C., Duncan, G. E., Buchwald, D., Willemsen, G., Skytthe, A., Kyvik, K. O., Christensen, K., Oncel, S. Y., Aliev, F., Rasmussen, F., Goldberg, J. H., Sorensen, T. I. A., Boomsma, D. I., Kaprio, J. & Silventoinen, K. 23 Jun 2016 In : Scientific Reports. 6, 13 p., 28496

    Publication: Contribution to journalA1 Refereed journal article

  5. Intrinsic resistance to PIM kinase inhibition in AML through p38a-mediated feedback activation of mTOR signaling

    Brunen, D., Jose Garcia-Barchino, M., Malani, D., Basheer, N. J., Lieftink, C., Beijersbergen, R. L., Murumagi, A., Porkka, K., Wolf, M., Zwaan, C. M., Fornerod, M., Kallioniemi, O., Angel Martinez-Climent, J. & Bernards, R. 21 Jun 2016 In : Oncotarget. 7, 25, p. 37407-37419 13 p.

    Publication: Contribution to journalA1 Refereed journal article

  6. iGEMS: an integrated model for identification of alternative exon usage events

    Sood, S., Szkop, K. J., Nakhuda, A., Gallagher, I. J., Murie, C., Brogan, R. J., Kaprio, J., Kainulainen, H., Atherton, P. J., Kujala, U. M., Gustafsson, T., Larsson, O. & Timmons, J. A. 20 Jun 2016 In : Nucleic Acids Research. 44, 11, 14 p., 109

    Publication: Contribution to journalA1 Refereed journal article

  7. BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

    Gu, Y., Helenius, M., Vaananen, K., Bulanova, D., Saarela, J., Sokolenko, A., Martens, J., Imyanitov, E. & Kuznetsov, S. 17 Jun 2016 In : Scientific Reports. 6, 9 p., 28217

    Publication: Contribution to journalA1 Refereed journal article

  8. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

    Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Ostman, B., Soderstrom, J., Pesonen, A-K., Martikainen, S., Räikkönen, K., Forsen, T., Hakaste, L., Almgren, P., Storm, P., Asplund, O., Shcherbina, L., Fex, M., Fadista, J., Tengholm, A., Wierup, N., Groop, L. & Mulder, H. 14 Jun 2016 In : Cell Metabolism. 23, 6, p. 1067-1077 11 p.

    Publication: Contribution to journalA1 Refereed journal article

  9. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

    Scott, R. A., Freitag, D. F., Li, L., Chu, A. Y., Surendran, P., Young, R., Grarup, N., Stancakova, A., Chen, Y., Varga, T. V., Yaghootkar, H., Luan, J., Zhao, J. H., Willems, S. M., Wessel, J., Wang, S., Maruthur, N., Michailidou, K., Pirie, A., van der Lee, S. J., Gillson, C., Al Olama, A. A., Amouyel, P., Arriola, L., Arveiler, D., Aviles-Olmos, I., Balkau, B., Barricarte, A., Barroso, I., Garcia, S. B., Bis, J. C., Blankenberg, S., Boehnke, M., Boeing, H., Boerwinkle, E., Borecki, I. B., Bork-Jensen, J., Bowden, S., Caldas, C., Caslake, M., Cupples, L. A., Cruchaga, C., Czajkowski, J., den Hoed, M., Dunn, J. A., Earl, H. M., Ehret, G. B., Ferrannini, E., Ferrieres, J., Foltynie, T., Ford, I., Forouhi, N. G., Gianfagna, F., Gonzalez, C., Grioni, S., Hiller, L., Jansson, J-H., Jorgensen, M. E., Jukema, J. W., Kaaks, R., Kee, F., Kerrison, N. D., Key, T. J., Kontto, J., Kote-Jarai, Z., Kraja, A. T., Kuulasmaa, K., Kuusisto, J., Linneberg, A., Liu, C., Marenne, G., Mohlke, K. L., Morris, A. P., Muir, K., Mueller-Nurasyid, M., Munroe, P. B., Navarro, C., Nielsen, S. F., Nilsson, P. M., Nordestgaard, B. G., Packard, C. J., Palli, D., Panico, S., Peloso, G. M., Perola, M., Peters, A., Poole, C. J., Quiros, J. R., Rolandsson, O., Sacerdote, C., Salomaa, V., Sanchez, M-J., Sattar, N., Sharp, S. J., Sims, R., Slimani, N., Smith, J. A., Thompson, D. J., Trompet, S., Tumino, R., van der A, D. L., van der Schouw, Y. T., Virtamo, J., Walker, M., Walter, K., Abraham, J. E., Amundadottir, L. T., Aponte, J. L., Butterworth, A., Dupuis, J., Easton, D. F., Eeles, R. A., Erdmann, J., Franks, P. W., Frayling, T. M., Hansen, T., Howson, J. M. M., Jorgensen, T., Kooner, J., Laakso, M., Langenberg, C., McCarthy, M. I., Pankow, J. S., Pedersen, O., Riboli, E., Rotter, J. I., Saleheen, D., Samani, N. J., Schunkert, H., Vollenweider, P., O'Rahilly, S., Deloukas, P., Danesh, J., Goodarzi, M. O., Kathiresan, S., Meigs, J. B., Ehm, M. G., Wareham, N. J., Waterworth, D. M., CVD50 Consortium, GERAD-EC Consortium, Neurology Working Grp, CHARGE, Alzheimer's Dis Genetics Consortiu, Pancreatic Canc Cohort Consortium, European Prospective Invest Into C, EPIC-InterAct, CHARGE Consortium, CHD Exome Consortium & CARDIOGRAM Exome Consortium 1 Jun 2016 In : Science translational medicine. 8, 341, 13 p., 341ra76

    Publication: Contribution to journalA1 Refereed journal article

  10. The DSM-5 diagnostic criteria for anorexia nervosa may change its population prevalence and prognostic value

    Mustelin, L., Silen, Y., Raevuori, A., Hoek, H. W., Kaprio, J. & Keski-Rahkonen, A. 1 Jun 2016 In : Journal of Psychiatric Research. 77, p. 85-91 7 p.

    Publication: Contribution to journalA1 Refereed journal article

  11. Acute-Phase Blood Pressure Levels Correlate With a High Risk of Recurrent Strokes in Young-Onset Ischemic Stroke

    Mustanoja, S., Putaala, J., Gordin, D., Tulkki, L., Aarnio, K., Pirinen, J., Surakka, I., Sinisalo, J., Lehto, M. & Tatlisumak, T. Jun 2016 In : Stroke. 47, 6, p. 1593-U450 8 p.

    Publication: Contribution to journalA1 Refereed journal article

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