Research Program in Genome-Scale Biology

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  1. 2012
  2. Inhibition of Transforming Growth Factor-Activated Kinase 1 (TAK1) Blocks and Reverses Epithelial to Mesenchymal Transition of Mesothelial Cells

    Strippoli, R., Benedicto, I., Perez Lozano, M. L., Pellinen, T., Sandoval, P., Lopez-Cabrera, M. & Angel del Pozo, M. 27 Feb 2012 In : PLoS One. 7, 2

    Publication: Contribution to journalA1 Refereed journal article

  3. Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

    Spain, S. L., Carvajal-Carmona, L. G., Howarth, K. M., Jones, A. M., Su, Z., Cazier, J-B., Williams, J., Aaltonen, L. A., Pharoah, P., Kerr, D. J., Cheadle, J., Li, L., Casey, G., Vodicka, P., Sieber, O., Lipton, L., Gibbs, P., Martin, N. G., Montgomery, G. W., Young, J., Baird, P. N., Morreau, H., van Wezel, T., Ruiz-Ponte, C., Fernandez-Rozadilla, C., Carracedo, A., Castells, A., Castellvi-Bel, S., Dunlop, M., Houlston, R. S. & Tomlinson, I. P. M. 15 Feb 2012 In : Human Molecular Genetics. 21, 4, p. 934-946 13 p.

    Publication: Contribution to journalA1 Refereed journal article

  4. Nearest neighbor analysis of dopamine D1 receptors and Na plus -K plus -ATPases in dendritic spines dissected by STED microscopy

    Blom, H., Ronnlund, D., Scott, L., Spicarova, Z., Rantanen, V., Widengren, J., Aperia, A. & Brismar, H. Feb 2012 In : Microscopy Research and Technique. 75, 2, p. 220-228 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  5. Brush border Myosin Ia has tumor suppressor activity in the intestine

    Mazzolini, R., Dopeso, H., Mateo-Lozano, S., Chang, W., Rodrigues, P., Bazzocco, S., Alazzouzi, H., Landolfi, S., Hernandez-Losa, J., Andretta, E., Alhopuro, P., Espin, E., Armengol, M., Tabernero, J., Ramon y Cajal, S., Kloor, M., Gebert, J., Mariadason, J. M., Schwartz, S., Aaltonen, L. A., Mooseker, M. S. & Arango, D. 31 Jan 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1530-1535 6 p.

    Publication: Contribution to journalA1 Refereed journal article

  6. 11q13 is a susceptibility locus for hormone receptor positive breast cancer

    Lambrechts, D., Truong, T., Justenhoven, C., Humphreys, M. K., Wang, J., Hopper, J. L., Dite, G. S., Apicella, C., Southey, M. C., Schmidt, M. K., Broeks, A., Cornelissen, S., van Hien, R., Sawyer, E., Tomlinson, I., Kerin, M., Miller, N., Milne, R. L., Pilar Zamora, M., Arias Perez, J. I., Benitez, J., Hamann, U., Ko, Y-D., Bruening, T., Chang-Claude, J., Eilber, U., Hein, R., Nickels, S., Flesch-Janys, D., Wang-Gohrke, S., John, E. M., Miron, A., Winqvist, R., Pylkas, K., Jukkola-Vuorinen, A., Grip, M., Chenevix-Trench, G., Beesley, J., Chen, X., Menegaux, F., Cordina-Duverger, E., Shen, C-Y., Yu, J-C., Wu, P-E., Hou, M-F., Andrulis, I. L., Selander, T., Glendon, G., Mulligan, A. M., Anton-Culver, H., Ziogas, A., Muir, K. R., Lophatananon, A., Rattanamongkongul, S., Puttawibul, P., Jones, M., Orr, N., Ashworth, A., Swerdlow, A., Severi, G., Baglietto, L., Giles, G., Southey, M., Marme, F., Schneeweiss, A., Sohn, C., Burwinkel, B., Yesilyurt, B. T., Neven, P., Paridaens, R., Wildiers, H., Brenner, H., Mueller, H., Arndt, V., Stegmaier, C., Meindl, A., Schott, S., Bartram, C. R., Schmutzler, R. K., Cox, A., Brock, I. W., Elliott, G., Cross, S. S., Fasching, P. A., Schulz-Wendtland, R., Ekici, A. B., Beckmann, M. W., Fletcher, O., Johnson, N., Silva, I. D. S., Peto, J., Nevanlinna, H., Muranen, T. A., Aittomäki, K., Blomqvist, C., Doerk, T., Schuermann, P., Bremer, M., Hillemanns, P., Bogdanova, N. V., Antonenkova, N. N., Rogov, Y. I., Karstens, J. H., Khusnutdinova, E., Bermisheva, M., Prokofieva, D., Gancev, S., Jakubowska, A., Lubinski, J., Jaworska, K., Durda, K., Nordestgaard, B. G., Bojesen, S. E., Lanng, C., Mannermaa, A., Kataja, V., Kosma, V-M., Hartikainen, J. M., Radice, P., Peterlongo, P., Manoukian, S., Bernard, L., Couch, F. J., Olson, J. E., Wang, X., Fredericksen, Z., Alnaes, G. G., Kristensen, V., Borresen-Dale, A-L., Devilee, P., Tollenaar, R. A. E. M., Seynaeve, C. M., Hooning, M. J., Garcia-Closas, M., Chanock, S. J., Lissowska, J., Sherman, M. E., Hall, P., Liu, J., Czene, K., Kang, D., Yoo, K-Y., Noh, D-Y., Lindblom, A., Margolin, S., Dunning, A. M., Pharoah, P. D. P., Easton, D. F., Guenel, P., Brauch, H. & KConFab Investigators, GENICA Network, Australian Ovarian Canc Study Grp 2012 In : Human Mutation. 33, 7, p. 1123-1132 10 p.

    Publication: Contribution to journalA1 Refereed journal article

  7. 15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells

    Lehtinen, L., Vainio, P., Wikman, H., Reemts, J., Hilvo, M., Issa, R., Pollari, S., Brandt, B., Oresic, M., Pantel, K., Kallioniemi, O. & Iljin, K. 2012 In : Internet Journal of Pathology. 226, 4, p. 674-686 13 p.

    Publication: Contribution to journalA1 Refereed journal article

  8. 19p13.1 Is a Triple-Negative-Specific Breast Cancer Susceptibility Locus

    Stevens, K. N., Fredericksen, Z., Vachon, C. M., Wang, X., Margolin, S., Lindblom, A., Nevanlinna, H., Greco, D., Aittomaki, K., Blomqvist, C., Chang-Claude, J., Vrieling, A., Flesch-Janys, D., Sinn, H-P., Wang-Gohrke, S., Nickels, S., Brauch, H., Ko, Y-D., Fischer, H-P., Schmutzler, R. K., Meindl, A., Bartram, C. R., Schott, S., Engel, C., Godwin, A. K., Weaver, J., Pathak, H. B., Sharma, P., Brenner, H., Mueller, H., Arndt, V., Stegmaier, C., Miron, P., Yannoukakos, D., Stavropoulou, A., Fountzilas, G., Gogas, H. J., Swann, R., Dwek, M., Perkins, A., Milne, R. L., Benitez, J., Pilar Zamora, M., Arias Perez, J. I., Bojesen, S. E., Nielsen, S. F., Nordestgaard, B. G., Flyger, H., Guenel, P., Truong, T., Menegaux, F., Cordina-Duverger, E., Burwinkel, B., Marme, F., Schneeweiss, A., Sohn, C., Sawyer, E., Tomlinson, I., Kerin, M. J., Peto, J., Johnson, N., Fletcher, O., dos Santos Silva, I., Fasching, P. A., Beckmann, M. W., Hartmann, A., Ekici, A. B., Lophatananon, A., Muir, K., Puttawibul, P., Wiangnon, S., Schmidt, M. K., Broeks, A., Braaf, L. M., Rosenberg, E. H., Hopper, J. L., Apicella, C., Park, D. J., Southey, M. C., Swerdlow, A. J., Ashworth, A., Orr, N., Schoemaker, M. J., Anton-Culver, H., Ziogas, A., Bernstein, L., Dur, C. C., Shen, C-Y., Yu, J-C., Hsu, H-M., Hsiung, C-N., Hamann, U., Duennebier, T., Ruediger, T., Ulmer, H. U., Pharoah, P. P., Dunning, A. M., Humphreys, M. K., Wang, Q., Cox, A., Cross, S. S., Reed, M. W., Hall, P., Czene, K., Ambrosone, C. B., Ademuyiwa, F., Hwang, H., Eccles, D. M., Garcia-Closas, M., Figueroa, J. D., Sherman, M. E., Lissowska, J., Devilee, P., Seynaeve, C., Tollenaar, R. A. E. M., Hooning, M. J., Andrulis, I. L., Knight, J. A., Glendon, G., Mulligan, A. M., Winqvist, R., Pylkas, K., Jukkola-Vuorinen, A., Grip, M., John, E. M., Miron, A., Alnaes, G. G., Kristensen, V., Borresen-Dale, A-L., Giles, G. G., Baglietto, L., McLean, C. A., Severi, G., Kosel, M. L., Pankratz, V. S., Slager, S., Olson, J. E., Radice, P., Peterlongo, P., Manoukian, S., Barile, M., Lambrechts, D., Hatse, S., Dieudonne, A-S., Christiaens, M-R., Chenevix-Trench, G., Beesley, J., Chen, X., Mannermaa, A., Kosma, V-M., Hartikainen, J. M., Soini, Y., Easton, D. F., Couch, F. J. & AOCS Grp, kConFab Investigators, GENICA Network 2012 In : Cancer Research. 72, 7, p. 1795-1803 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  9. A Boolean Approach for Disentangling the Roles of Submodules to the Global Properties of a Biomodel

    Czeizler, E. & Petre, I. 2012 In : Fundamenta Informaticae. 116, 1-4, p. 51-63 13 p.

    Publication: Contribution to journalA1 Refereed journal article

  10. A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer

    Pelttari, L. M., Kiiski, J., Nurminen, R., Kallioniemi, A., Schleutker, J., Gylfe, A., Aaltonen, L. A., Leminen, A., Heikkilä, P., Blomqvist, C., Butzow, R., Aittomäki, K. & Nevanlinna, H. 2012 In : Journal of Medical Genetics. 49, 7, p. 429-432 4 p.

    Publication: Contribution to journalA1 Refereed journal article

  11. A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers

    Nevanlinna, H., Aittomäki, K. & SWE-BRCA, HEBON, EMBRACE, GEMO Study Collaborators, KConFab Investigators, OCGN, Consortium Investigators Modifiers 2012 In : Cancer Epidemiology, Biomarkers & Prevention. 21, 8, p. 1362-1370 9 p.

    Publication: Contribution to journalA1 Refereed journal article