Yan-Ru Lou


Research areas

Description of research and teaching

Key research interests

Tissue engineering for drug research

My research focuses on developing functional and predictive cell-based tools for drug research and personalized medicine. We use stem cells- and biomaterials-based tissue engineering approach to produce functional cells and tissues. We have developed flexible, dynamic three-dimensional (3D) culture systems for human pluripotent stem cells (human embryonic stem cells and induced pluripotent stem cells) and human cancer cells. The current specific objective is to generate functional hepatocytes with 3D configuration as drug development tools for drug and chemical testing. We apply advanced cell culture technologies and novel biomaterials, along with molecular biology methods. Our research not only develops new cell-based technologies but also advance fundamental understanding of how matrix and biomaterials affect cell behavior and performance.



Cell-biomaterials interactions, pharmaceutical and medical applications (lecture course 590284, 3 credits)

In vitro drug permeability (Advanced biopharmaceutics practicals 590289)


Curriculum Vitae

Short curriculum vitae


BSc in Pharmacy, School of Pharmacy, West China University of Medical Sciences, Chengdu, China, 1996

PhD in Molecular Endocrinology, Faculty of Medicine, University of Tampere, Finland, 2005

Academic posts

Pharmacist, Institute for Drug Control, Xi'An, China, 1996-1999

Researcher, University of Tampere, Tampere, Finland, 1999-2006

Senior researcher, REGEA Institute for Regenerative Medicine, Tampere, Finland, 2006-2007

Research scientist, A*STAR Institute of Bioengineering and Nanotechnology (IBN), Singapore, 2007-2009

Principal investigator, University of Helsinki, Helsinki, Finland, 2009-


Latest publications

  1. Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier

    Baghirov, H., Karaman, D., Viitala, T., Duchanoy, A., Lou, Y-R., Mamaeva, V., Pryazhnikov, E., Khiroug, L., Davies, C. D. L., Sahlgren, C. & Rosenholm, J. M. 22 Aug 2016 In : PLoS One. 11, 8, 22 p., 0160705

    Publication: Contribution to journalA1 Refereed journal article

  2. Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix

    Kanninen, L. K., Porola, P., Niklander, J., Malinen, M. M., Corlu, A., Guguen-Guillouzo, C., Urtti, A., Yliperttula, M. L. & Lou, Y-R. 15 Feb 2016 In : Experimental Cell Research. 341, 2, p. 207-217 11 p.

    Publication: Contribution to journalA1 Refereed journal article

View all (46) »

Latest activities

  1. Master's thesis supervision

    Yan-Ru Lou (Supervisor), 7 Jan 201631 Jul 2016

    Activity: Thesis supervision, mentoring and examinationSupervision of other thesis (Master's, Licentiate)

  2. Academic visit to start collaborations in research and teaching

    Yan-Ru Lou (Visiting lecturer), 12 Jan 201519 Jan 2015

    Activity: International Mobility: VisitsAcademic visit to other institution

  3. Stem Cells and Development

    Yan-Ru Lou (Reviewer), Mar 2015

    Activity: Editorial work / peer reviewPeer review of manuscripts

View all (62) »

Latest projects

  1. Stem cell-derived, three-dimensional liver: the missing link in drug discovery

    Lou, Y., Harjumäki, R., Kanninen, L., Smutný, T., Bogacheva, M., Salmi, T. & Makhdoom, Y.



    Project: Research project

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